Cardiovascular Detective, Inc. was formed to meet the increasing need for outsourcing pre-clinical contract research in the field of cardiovascular research. There are many CRO's that offer similar services, however, Cardiovascular Detective is the only organization that is a network of highly trained university scientists in the field of cardiovascular research.

General Capabilities

• Hemodynamics Screening
• Conscious Rodent Telemetry (BP, HR, RF)
• Conscious Rodent Tethering (BP, HR, RF)
• Aortic & mesenteric reactivity & vascular stiffening
• Renal Function Screening
• Cardiac hemodynamics (dp/dt, LVSP, LVEDP)
• Isolated aortic rings
• Isolated heart
• Echocardiography (EF, CO, LVDD, LVSD)
• Doppler echocardiography measurement of PA flow velocity
• Catheter-based measurements of LV, RV, and PVR 

Heart Failure

• Isoproterenol and Angiotensin-induced models of cardiac hypertrophy and fibrosis
• LAD coronary artery ligation in mice and rats
• Transverse aortic constriction in mice and rats
• Dahl SS model of diastolic heart failure
• DOCA-Salt + Unilateral Nephrectomy Rats
• Tachypacing induced model in rabbits and dogs
• Myocardial Ischemia/Reperfusion

Pulmonary Hypertension

• Hypoxia-induced pulmonary hypertension in mice and rat
• Hypoxia induced plus SU5416 (VEGF-R inhibitor) pulmonary hypertension in mice and rats
• Neonatal calf hypoxia
• Monocrotaline-induced pulmonary fibrosis (arterial fibrosis leading to hypertension)

Clinical R&D, Regulartory and Ethics Submission

• Focusing on unique clinical trials that need sensitive patient population and strong regularoty & scientific support
• Qualified and expereienced investigators and cetners (e.g. phase 1 centers)
• Our clinical pharmacology specialists are ready to assist your project

For additional information, please visit: www.cardiodetective.com